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1994-09-24
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Document 0707
DOCN M9490707
TI Methadone treatment as a determinant of HIV risk reduction among
injecting drug users: a nested case-control study.
DT 9411
AU Serpelloni G; Carrieri MP; Rezza G; Morganti S; Gomma M; Binkin N;
Gruppo C, ULSS-25, Verona, Italy.
SO AIDS Care. 1994;6(2):215-20. Unique Identifier : AIDSLINE MED/94339212
AB In order to evaluate the protective effect of methadone treatment on HIV
infection, we performed a nested case-control study on seroconverters
(cases) who were part of a cohort of HIV-negative injecting drug users
(IDUs) (controls). Controls were matched with cases by sex, age,
duration of drug use and follow-up time. Information on methadone
treatment in the year prior to seroconversion was collected using
clinical registries. Univariate and multivariate conditional logistic
regression were used to identify variables related to
HIV-seroconversion. The study included 40 cases and 40 controls.
Univariate analysis showed the following variables to be associated to
HIV seroconversion: number of cycles of treatment, daily dose and time
out of treatment. After performing multivariate analysis, daily dose
remained protective with a linear effect noted even at low doses and
time out of treatment was the most important risk factor. The risk
increased 1.5 times for every 3 months spent out of treatment. Long-term
methadone treatment protects against HIV infection. Its effect may be
attributable to a reduction in the frequency of injecting drug use or to
an increased knowledge of risk factors following counselling in drug
centres.
DE Adolescence Adult Case-Control Studies Cohort Studies Dose-Response
Relationship, Drug Drug Administration Schedule Female Follow-Up
Studies Human HIV Infections/*PREVENTION &
CONTROL/PSYCHOLOGY/TRANSMISSION Italy Knowledge, Attitudes, Practice
Longitudinal Studies Male Methadone/ADVERSE EFFECTS/*THERAPEUTIC USE
Middle Age Narcotic Dependence/COMPLICATIONS/PSYCHOLOGY/*REHABILITATION
Patient Education Prospective Studies Risk Factors Substance Abuse,
Intravenous/COMPLICATIONS/PSYCHOLOGY/ *REHABILITATION JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).